COVID-19 Update

Situation in Canada with Vaccinations and New Variants

At the end of November and beginning of December, the COVID-19 pandemic continues to persist around the world, including Canada.

As of December 9 in Canada, according to the Public Health Agency of Canada (PHAC), there have been 1,818,742 cumulative COVID-19 cases. Worldometers reports that there are 31,197 active cases and 1,760,830 people have recovered, and 29,863 people have died of the disease. Current cases and vaccinations are shown in the two maps below:

The changing levels of daily new cases and new deaths since the start of pandemic are shown in the two graphs below:

In the context of the Delta variant, which now makes up the majority of current cases, and the emerging Omicron variant, Dr. Theresa Tam, Chief Public Health Officer of Canada, in her December 10 statement, noted:

"Today's updated longer-range modelling forecast suggests that with our current levels of transmission a resurgence of Delta variant cases is forecasted for Canada, even without any acceleration of the Omicron variant in Canada [...]. The forecast also shows a possible trajectory if spread of the Omicron variant were to accelerate and replace the Delta variant as the predominant variant in Canada. In this case [...], it is possible we could have an even more rapidly accelerating resurgence in cases. As well, while there is still considerable uncertainty regarding the potential for Omicron to evade immunity and/or increase disease severity, any rapid resurgence in cases could add additional strain to our still fragile health care system. Until we know more, Omicron's increased transmissibility and potential for strong resurgence means we must approach the coming weeks with an abundance of caution and at the same time be prepared to act quickly to control spread at the first sign of rapidly accelerating cases."

As of December 9, the PHAC reports that cases of the Omicron variant have been confirmed in seven jurisdictions: Quebec, Ontario, Manitoba, Saskatchewan, Alberta, British Columbia and the Yukon Territory. Regarding the efficacy of vaccines against this new variant of concern, Dr. Tam explains:

"Despite the challenges ahead with the continuing Delta-driven wave in Canada and emergence of the Omicron variant, we have more and better protections going into this holiday and winter season than previously. Vaccines and our expanding population coverage continue to give us an advantage over this virus, and while some reduction in protection is possible with the Omicron variant, COVID-19 vaccines are still expected to provide a level of protection, particularly against severe outcomes. Hence, vaccination including boosters, in combination with layers of public health and personal protections, continues to be essential to the pandemic response in Canada.

"Since the start of the pandemic, there have been 1,823,009 cases of COVID-19 and 29,876 deaths reported in Canada. These cumulative numbers tell us about the overall burden of COVID-19 illness to date, while the number of active cases, now at 31,295, and seven-day moving averages indicate current disease activity and severity trends.

"Surveillance data continue to show significant regional variation in COVID-19 disease activity across the country. Nationally, daily case counts are rising with high infection rates persisting in many areas. During the latest seven-day period (December 3-9), an average of 3,450 new cases were reported, which is an increase of 22 per cent compared to the previous week. Currently, hospitalization and critical care admission trends, which are lagging indicators, have levelled off, but if infection rates accelerate, trends could begin to rise again. The latest provincial and territorial data show that an average of 1,457 people with COVID-19 were being treated in Canadian hospitals each day during the most recent seven-day period (December 3-9), which is five per cent lower than last week. This includes, on average, 458 people who were being treated in intensive care units (ICU), 1.6 per cent less than last week and an average of 20 deaths were reported daily (December 3-9). Keeping infection rates down remains key to avoiding renewed increases in severe illness trends over the coming weeks and months as well as to ease longer term strain on the health system, particularly in heavily impacted areas.

"While Delta continues to represent the vast majority of recent COVID-19 cases in Canada, as of December 9, 2021, there have been 87 cases with the newly designated variant of concern (VOC), Omicron, reported in seven provinces and territories. As we continue to assess the significance and impact of this new VOC, Canadians are urged to remain vigilant and continue maintaining layers of protection.

"Regardless of which SARS-CoV-2 variant is circulating, we know that vaccination, in combination with public health measures and individual practices, work to reduce disease spread and severe outcomes. In particular, evidence continues to demonstrate that a complete two-dose series of Health-Canada approved COVID-19 vaccines provides substantial protection against severe illness due to the predominating Delta variant, particularly among younger age groups. Based on the latest data from 10 provinces and territories for the population aged 12 years or older, in recent weeks (October 24 - November 20, 2021) and adjusting for age, average weekly rates indicate that unvaccinated people were significantly more likely to be hospitalized with COVID-19 compared to fully vaccinated people.

"Among youth and adults aged 12 to 59 years, unvaccinated people were 32 times more likely to be hospitalized with COVID-19 than fully vaccinated people.

"Among older adults aged 60 years or older, unvaccinated people were 16 times more likely to be hospitalized with COVID-19 than fully vaccinated people."

In her December 3 statement, Dr. Tam informed of the National Advisory Committee on Immunization (NACI) recommendations on third doses of the vaccines to boost immunization. She stated:

"NACI has reaffirmed that the benefits of receiving an mRNA COVID-19 vaccine continue to outweigh any potential risks of experiencing rare side effects following vaccination with an mRNA vaccine, including the rare risk of vaccine-associated myocarditis and/or pericarditis most often seen in males aged 12 to 29 years. NACI also recommends, and health authorities in Canada agree, that immunization in those who are eligible -- but have yet to receive their primary series -- should continue to remain the top priority, in Canada and around the world.

"Regarding boosters, NACI considered emerging evidence on waning protection of vaccines over time and the safety and potential benefits of mRNA vaccine booster doses. In the context of the Delta variant, evidence suggests that vaccine effectiveness against infection and symptomatic disease decreases with time, and possibly against severe illness as well, especially in older individuals. No additional safety concerns were noted following mRNA vaccine booster doses. The rare risk of myocarditis and/or pericarditis appears to be lower after the booster dose than after the second dose of the primary series --though higher than after the first dose. Based on this, NACI has increased the strength of their recommendations to now say --a booster dose of an authorized mRNA COVID-19 vaccine should be offered 6 months or more after completion of a primary COVID-19 vaccine series."

However, the World Health Organization (WHO) has advised against the rollout of booster shots by wealthy nations, saying that it comes at the expense of access to vaccines by poorer countries. The WHO and the Strategic Advisory Group of Experts on Immunization and its COVID-19 Vaccines Working Group, which "continues to review the emerging evidence on the need for and timing of a booster dose for the currently available COVID-19 vaccines," in an October 4 update concluded that:

"Introducing booster doses should be firmly evidence-driven and targeted to the population groups in greatest need. The rationale for implementing booster doses should be guided by evidence on waning vaccine effectiveness, in particular a decline in protection against severe disease in the general population and in high-risk populations, or due to a circulating VOC [variant of concern]. To date, the evidence remains limited and still inconclusive on any widespread need for booster doses following a primary vaccination series.

"In the context of ongoing global vaccine supply constraints, broad-based administration of booster doses risks exacerbating inequities in vaccine access by driving up demand and diverting supply while priority populations in some countries, or in subnational settings, have not yet received a primary vaccination series. The focus remains on urgently increasing global vaccination coverage with the primary series driven by the objective to protect against severe disease."

(With files from PHAC, WHO)


This article was published in

Volume 51 Number 12 - December 12, 2021

Article Link:
https://cpcml.ca/Tmlm2021/Articles/M510123.HTM


    

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